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Are you Aware of Cough Hypersensitivity Syndrome?

Javeria Usmani


November 15, 2021
CoughPro is not a medical product. It is a wellness app intended only for users to obtain a better understanding of their cough. It is not intended to diagnose, monitor, or treat any illness.

We at Hyfe, Inc., are a company devoted to working on tools to better understand the importance of cough. It is Hyfe’s intention in the future to seek regulatory approval for medical products that analyze cough in order that they may be used to diagnose, monitor, and facilitate better treatment of respiratory illnesses.

Cough Hypersensitivity

Does cough hypersensitivity syndrome differ from a chronic cough? Experts define it as a cough in response to a stimulus. Whereas persistent or chronic cough lasts for at least eight weeks.

The following chronic cough conditions may show hypersensitivity towards certain stimulants:

  • Asthma (associated with cough)
  • Chronic Bronchitis
  • COPD
  • Emphysema
  • Pneumonia

Three good examples are: 

  • cough variant asthma.
  • idiopathic cough (typically lasts more than three weeks). 
  • cough induction due to reflux.

Causes of Cough Hypersensitivity

There are various types of stimuli:

  • Smoke
  • Chemicals
  • Dust
  • Mites/Ticks
  • Smog
  • Fog
  • Perfume

Cold weather, physiologic triggers, simply talking and laughing hard can also act as stimuli.

This often occurs due to one of three types of exposure:

  • Chemical exposure - For instance, exposure to chemicals that are irritants.
  • Thermal exposure - When you come in contact with temperature or heat is thermal exposure.
  • Mechanical exposure - Applying high physical effort, which may lead to fatigue, is considered mechanical exposure.

Remember that stimuli, such as those listed above, do not necessarily make you cough every time. 

Symptoms of Cough Hypersensitivity

Initially patients' complaints of various sensations and symptoms undergoing hypersensitivity.

Some signs are

  • Throat irritation
  • Unexplainable sensation
  • Difficulty in breathing
  • Tickling
  • Itchiness in the respiratory tract
  • Laryngeal Paraesthesia 

Laryngeal Dysfunction in Hypersensitivity Syndrome: A Cross-Sectional Observational Study shows: deterioration of the vocal cords is quite common in CHS. 

Read this interesting yet powerful research study to learn about the Expert opinion on the cough hypersensitivity syndrome in respiratory medicine by the European Respiratory Society.

Tools to Measure Cough Hypersensitivity

Using cough frequency and cough reflex sensitivity tools can help measure the hypersensitivity.

Below are a few tools by name that were detailed in a study Hypersensitivity Syndrome: A Few More Steps Forward research:

  • Tussigen inhalation challenge test 
  • Hull Automated Cough Counter
  • Leicester Cough Monitor
  • VitaloJAK
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Diagnosis of Cough Hypersensitivity Syndrome

Sadly, there is no specific diagnostic test or technique to detect this type of cough. Although, its diagnosis is not a big challenge. We might need special testing procedures in the future to find more accurate results.

A  physician may ask you a few questions about your condition. Describing your signs and symptoms in detail will help the healthcare provider assist you accordingly. 

It is essential to identify and point out the reason behind the trigger, whether it be chemical, physiological, thermal, or mechanical stimuli.  This information may be fundamental to diagnose the issue efficiently.

Often, simple cough sensitivity tests help in screening, such as by inhaling citric acid (vitamin C) or capsaicin (the active ingredient of chili pepper).

Treatment of Cough Hypersensitivity Syndrome

Involving treatment of speech pathology can aid in laryngeal dysfunction. 

Drugs such as amitriptyline and gabapentin treat chronic pain. They also act as antitussive agents. In addition, randomized clinical studies have demonstrated gabapentin medicine as effective against chronic coughing patients having laryngeal sensory neural damage.


To date, researchers have not produced as many studies about chronic hypersensitivity syndrome as would be ideal for substantially advancing the field. Therefore, more research is needed, especially in identifying approaches to improve outcomes of patients with cough hypersensitivity syndrome.

This insightful resource provides an overview of cough hypersensitivity progress at the Tenth London International Cough Symposium 2018.


  1. Chronic cough hypersensitivity syndrome | Cough | Full Text (biomedcentral.com)
  2. – A Major Advance in the Understanding of Chronic Cough | touch respiratory
  3. clinical measurement is the key to progress | European Respiratory Society (ersjournals.com)
  4. Drug-induced Cough - Hyfe Blog (hyfeapp.com)
  5. Smoker’s Cough: Everything You Should Know - Hyfe Blog (hyfeapp.com)

Your Cough Matters

Based on our results in Google Play & App Store
  • Excellent, insightful
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    App is great at tracking cough when little ones are sick. I treat it as a early warning indicator before the cold gets back. Customer service is awesome, they actually respond to all my questions.
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    I had an issue logging into the new app but I contacted the support team and they were awesome in helping me figure out the issue. It turned out to be a technical issue which they resolved very quickly and I was kept in the loop on the status from start to finish. This app is really helpful when talking to my doctor too..
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    By KayakTina - Apr 7, 2023 - App Store
    "The app accurately is recording my coughs with excellent ways to review the results. I can add notes to help me identify patterns or have accurate information for my physicians. I’ve hoped for an app like this for years to help me accurately track the amount of coughing I’m doing"
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